• Slideshow
  • Slideshow
  • Slideshow
  • Slideshow
  • Slideshow
 

Editorial by Jorge Andrade and Michael Potente published in EMBO Journal

14.08.2017 by Michael Potente

The News & Views article discusses two new studies published in the EMBO Journal that highlight the importance of glutamine metabolism in endothelial cells. These reports show that glutamine is a crucial TCA cycle carbon source in endothelial cells that supports cell proliferation, biomass synthesis and vessel growth.

 

Link to the articles by Huang et al and Kim et al.

 

 

Great honor for Kerstin Wilhelm – recipient of the 2016 Otto Hahn Medal

25.06.2017 by Michael Potente

On June 21, Dr. Kerstin Wilhelm from the Angiogenesis & Metabolism Laboratory at the Max Planck Institute was awarded an Otto Hahn Medal. The award is given by the Max Planck Society and honors young junior scientists for their scientific accomplishments during their Ph.D. Kerstin Wilhelm received this prestigious prize for her work on the molecular regulation of blood vessel growth, a process generally referred to as angiogenesis. The award ceremony took place in Weimar during the Annual Meeting of the Society.

 

Since 1978 the Max Planck Society honors up to 30 young scientists per year with the Otto Hahn Medal for outstanding scientific achievements. It comes with a monetary award of 7500 euros as recognition. The prize is intended to motivate especially gifted junior scientists and researchers to pursue a future university or research career.

 

Further informations.

 

 

 

 

New review article by Michael Potente and Taija Mäkinen

25.05.2017 by Michael Potente

Blood and lymphatic vessels have essential roles in physiology and disease. Endothelial cells that line these vessel networks specialize to fulfil the needs of the tissue that they pervade. Recent studies in animal models have provided insights into the mechanisms underlying vessel type- and organ-specific differentiation, which is crucial for the understanding of vessel type- and vascular bed-specific diseases. This review summarizes the molecular and functional heterogeneity within the vasculature and discusses emerging concepts of endothelial specialization.

 

Link to the review article & link to the journal.

Kerstin Wilhelm awarded with the 2017 Werner-Risau-Prize

05.03.2017 by Michael Potente

Kerstin Wilhelm from the Max Planck Institute for Heart and Lung Research has been awarded the Werner-Risau-Prize 2017 by the German Society for Cell Biology. The prize was awarded to her at the annual meeting in Leipzig.

 

Kerstin Wilhelm received the award for her work on the forkhead transcription factor FOXO1. The 29-year-old scientist had discovered that FOXO1 is an important regulator of blood vessel growth, which suppresses the metabolic and proliferative activities of endothelial cells – the cells that line the inner surface of blood vessels. Since a number of diseases are associated with aberrant vascular growth, the discovery of FOXO1 as an essential negative regulator of blood vessel formation could therapeutic implications. “For instance, the growth of tumors could be slowed by inhibiting the formation of tumor vessels through targeted FOXO1 activation,” says Wilhelm.

 

The German Society for Cell Biology awards the Werner-Risau-Prize for the outstanding work of young scientists in the field of endothelial cell biology.

New review article by Michael Potente and Peter Carmeliet

18.12.2016 by Michael Potente

In the forthcoming issue of Annual Review of Physiology, a review article by Michael Potente and Peter Carmeliet will be published. The article has the title “The link between angiogenesis and endothelial metabolism” and discusses the role of endothelial metabolism for vessel growth and function. In this review, Michael and Peter take a cell biological perspective to explain the metabolic requirements of sprouting vessels, and to highlight the cellular consequences of altering specific metabolic pathways in endothelial cells. They also explain how endothelial cells sense changes in their metabolic microenvironment, and how changes in EC metabolism can contribute to disease.

The article is already available online on the website of Annual Reviews.

Congratulations to Radiance Lim for obtaining her Ph.D. degree

03.12.2016 by Michael Potente

On November 28th, Radiance Lim from Singapore successfully defended her Ph.D. thesis at the University of Cologne. In her studies, she investigated the role of deubiquitinating enzymes (DUBs) in the regulation of endothelial Notch signaling.

 

 

 

 

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ANGIOGENESIS & METABOLISM LABORATORY
ANGIOGENESIS & METABOLISM LABORATORY
ANGIOGENESIS & METABOLISM LABORATORY
ANGIOGENESIS & METABOLISM LABORATORY