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EU funding for international research and training project into vascular anomalies

01.10.2018 by Michael Potente

The Angiogenesis & Metabolism Laboratory is part of the international V.A. Cure research network that will receive 3.7 million euros of EU funding from the MSCA-ITN programme (Marie Skłodowska-Curie Actions) to study vascular anomalies.

 

Vascular anomalies are a group of rare vascular diseases, characterized by localized developmental defects of blood or lymphatic vessels, which are present at birth or appear in early childhood. For many of these disorders, no cure exists, and many patients need life-long clinical treatment. Treatment success is often partial and patients with chronic pain, dysfunction and lowered quality of life.

 

The V.A. Cure network will study in depth the genetic mutations and signalling pathways that drive vascular anomalies. While pursuing this research, the network will coach 14 PhD students in diverse aspects of biology and biomedicine with the aim to train the next generation of vascular biologists.

The network consists of seven academic partners from all over Europe including the de Duve Institute (Belgium), University of Uppsala (Sweden), Max Planck Institute for Heart and Lung Research (Germany), Karolinska Institute (Sweden), University of Potsdam (Germany), University of Oulu (Finland) and INSERM (France)). The network is complemented by AstraZeneca (Sweden) and FinnAdvance (Finland), two companies with a strong interest in basic biomedical research.

 

“This is a fantastic opportunity for our network to recruit young scientists to the field of vascular biology and the study of vascular anomalies. Vascular anomalies have been neglected for a long time, yet our earlier research has opened doors for better understanding and development of precisions therapies. As blood and lymphatic vessels are implicated in various diseases, we also expect the data produced by this network to be applicable in many other areas of vascular biology and vascular diseases,” says project coordinator Prof. Miikka Vikkula of the de Duve Institute, UCL, Brussels, Belgium.

EU funding for international research and training project into vascular anomalies
The V.A. Cure Network (from right to left):  Salim Seyfried, Miikka Vikkula, Lauri Eklund, , Sabine Bailly, Lars, Jakobsson, Taija Mäkinen, Michael Potente

Toshiya Sugino wins an EMBO Poster Award

09.09.2018 by Michael Potente

Dr. Toshiya Sugino received an award for his outstanding poster presentation at the Frankfurt Conference on Quality Control in Life Processes, which took place from September 2 to 6, 2018. He presented his work on the regulation of FOXO transcription factors by deubiquitinating enzymes. This prize was sponsored by The EMBO Journal and is a great recognition of his science.

 

 

 

 

Toshiya Sugino wins an EMBO Poster Award

Poster prize winners at this year’s Frankfurt Conference on Quality Control in Life Processes. Toshiya Sugino is on the right.

Editorial by Radiance and Michael published in Circulation

09.07.2018 by Michael Potente

Here is the introduction of the editorial “Top-NOTCH Regulation of Cardiac Metabolism“:

 

The adult human heart is a fascinating organ. Despite weighing no more than 300 g (on average), it pumps 8 tons of blood through 60 000 miles of blood vessels each day. This remarkable performance is energetically demanding and consumes ≤10% of the body’s energy. However, the heart has little capacity for energy storage and thus relies on the continuous supply of exogenous metabolic resources.

 

Under physiological conditions, the heart muscle uses fatty acids as a primary energy source. The muscle cells (cardiomyocytes) oxidize this energetic fuel in mitochondria to efficiently generate cellular energy in the form of ATP. Fatty acids are delivered to cardiomyocytes via a dense network of capillaries, whose interior is lined by a continuous layer of endothelial cells specialized for fatty acid transport. Unlike endothelial cells in many other vascular beds (eg, brain), these cells are rich in transporters and binding proteins that mediate the transcellular flux of blood-borne fatty acids to perivascular tissues. The importance of this tailored nutrient delivery is evident in disease. Indeed, a number of cardiomyopathies that lead to myocardial hypertrophy, dysfunction, and failure are associated with alterations in fatty acid utilization and cardiac energy metabolism.However, the mechanisms that regulate nutrient transfer in the heart are poorly understood.

 

In a recent issue of Circulation, Jabs et al shed light on this question by reporting that endothelial Notch signaling critically regulates fatty acid transport capacity, thereby determining cardiac metabolism and function. These findings are interesting not only because of their medical implications, but also because they add to the emerging picture that organ-specific endothelial cells exert crucial gatekeeper functions that actively regulate and maintain tissue homeostasis.

For further reading please visit the homepage of Circulation.

Angiogenesis & Metabolism Lab is part of a successful Leducq grant application

08.07.2018 by Michael Potente

Together with five other international scientists, Michael Potente was awarded a Leducq research grant of US$ 6 million. The transatlantic network will study a transcription factor called Kruppel-like factor (KLF) 2, which plays pivotal roles in cardiovascular physiology and disease. The researchers believe that a detailed analysis of this single factor is likely to make breakthroughs in our understanding of important cardiovascular and lymphatic diseases.

 

The network is coordinated by Martin Schwartz (Yale University) and Ralf Adams (Max Plank Institute for Molecular Biomedicine) and brings together a group of investigators with expertise in vascular biomechanics, metabolism, gene transcription, mouse genetics and disease models. The team is complemented by Sarah De Val (University of Oxford), Mukesh Jain (Case Western Reserve University), Mark Kahn (University of Pennsylvania), and Michael Potente (Max Plank Institute for Heart and Lung Research), who work closely together to understand KLF2 regulation and function in diverse biologic settings.

 

The five-year project is one of only five projects that are funded in this year’s call. The grant is intended to promote joint research between

Europe and the USA and is given by the Leducq Foundation, a French-American foundation that aims to fight cardiovascular diseases worldwide.

 

Link to official press release.

Say “Hi” to Jannik Fasse – new team member in the lab

15.05.2018 by Michael Potente

On April 1, 2018 Jannik Fasse joined the Angiogenesis & Metabolism Laboratory. Jannik studies medicine at the Justus Liebig University in Giessen where he completed his “Physikum” (preliminary medical examination) with distinction in 2017. He now aims to do his medical thesis (Dr. med.) in a basic science laboratory. His work will be supported by a scholarship from the German Center for Cardiovascular Research (DZHK), which enables him to devote a significant amount of time on cardiovascular research. Together with Kerstin Wilhelm, he will work on the role of FOXO transcription factors in the endothelium. We are delighted that Jannik joined our team and look forward to making new scientific discoveries together.

 

 

Say “Hi” to Jannik Fasse - new team member in the lab

From left to right: Michael, Jannik & Kerstin

Merry Christmas and Happy New Year!

26.12.2017 by Michael Potente

Some photos from this year’s Christmas Party at the Schirn in Frankfurt.

 

 

 

 

 

 

 

 

 

Merry Christmas and Happy New Year!

Just before the dinner at the Badias. From upper left to right: Jorge Andrade, Kerstin Wilhelm, Michael Potente, Toshiya Sugino, Yu-Ting Ong, Barbara Zimmermann, Anuradha Doddaballapur, Chenyue Shi.

 

Merry Christmas and Happy New Year!

Inner circle.

 

Merry Christmas and Happy New Year!

Looking forward to 2018!

Toshiya Sugino wins an EMBO Poster Award
2018-09-09 15:38:20,
by Michael Potente
Editorial by Radiance and Michael published in Circulation
2018-07-09 10:35:46,
by Michael Potente
Say “Hi” to Jannik Fasse – new team member in the lab
2018-05-15 13:36:56,
by Michael Potente
Merry Christmas and Happy New Year!
2017-12-26 15:18:44,
by Michael Potente
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